SRC-7™ – Skin Regeneration Complex – Advanced Stem Cell Technology Complex (Patent Pending)

In keeping with our dedication to the principles of making use of the most advanced technology available for skin care, our proprietary skin regeneration complex has been upgraded to include the very best and latest technology for achieving more youthful skin appearance and collagen development. Based upon our eight years of research and experience with stem cell components in skin care, and the very latest research knowledge shared by scientists around the world, we have created an advanced complex of ingredients which is like nothing else in the world. We are calling this patent-pending complex SRC-7™.

As we stated earlier there has been much progress made in understanding the different stem cell types in the skin and how they perform their unique function. The latest research work in the contribution of stem cells resident in skin tissues indicates a multi-faceted contribution in the process of skin repair and renewal. Scientific study has now identified at least three stem cell types which contribute to skin regeneration.

Epidermal Stem Cells

The epidermis is the perfect example of a self-renewing tissue. The stem cell responsible for this renewal is the highly differentiated, tissue specific, epidermal stem cell (ESC) which resides at the basal layer of the epidermis (Figure 1). This stem cell type is differentiated to the point of producing only new cells specific to the epidermis. These ESC’s continually differentiate into daughter cells (also called TA cells), new epidermal stem cells, and, of course, new epidermal skin cells of various types. These cells provide the new epidermal growth needed for the day to day replacement of the outer layer Stratum Corneum (SC) barrier, as exfoliated keratin is lost to the environment. The proliferation capacity of these cells and of their next progeny defines the epidermal turnover rate. With age, the rate of replacement of the SC is reduced, making it thinner, more fragile, and more likely to suffer from impaired wound healing (typically skin thickness lessens by about 10% per decade). ESC’s also play a role in the accelerated repair of the epidermal area when needed due to trauma. Summarizing … Epidermal stem cells are responsible for the continued requirement of replacing the outer layers of our skin and tend to perform less with age causing our skin to become thinner; they also aid in healing when skin trauma occurs.

Technology - epidermal cross section
Figure 1 – Epidermal Cross Section

 

Follicular Stem Cells/Dermal Stem Cells (DSC)

In human skin, subpopulations of stem cells reside in the hair follicle bulb; among these are mesenchymal stem cells (MSC). MSC’s are multi-potent stem cells found throughout the body and provide the general tissue repair and restore function within the structures of the human body. In this particular locale (the dermal papilla) these stem cells exhibit the important expected behavior of self-renewal, while some also migrate into the dermis where they proliferate and differentiate into fibroblast cells (see figure 2). These fibroblast cells provide regeneration for the extracellular matrix (ECM) by producing new collagen and elastin, which is constantly being required to maintain skin elasticity, firmness, and a strong supporting structure. In the case of both aging and wound repair these MSC’s in the dermal papilla are essential for achieving rapid and effective rejuvenation by differentiating into fibroblasts and providing new, needed, collagen and elastin in the ECM. As with ESC’s the number of DSC’s often decline with age and they fail to produce the collagen and elastin needed for dermal layer support of the skin. Aging Dermal Stem Cells are less effective in generating new fibroblasts, and thus new collagen. This causes a loss of collagen with age and a loss of youthful facial structure.

Technology - skin cross section
Figure 2 – Skin cross section showing follicular stem cells in dermal layer and adipose stem cells in hypodermis

 

Hypodermal Stem Cells/Adipose Stem Cells

In addition to the tissue specific epidermal stem cells and the hair follicle bulb mesenchymal stem cells, which shall be referred to as “dermal stem cells” (DSC), recent discovery has found a vast number of mesenchymal stem cells in the hypodermis which lies below the dermal layer of the skin (see figure 3). Research in the past few years has discovered that literally millions of Adipose stem cells reside in the hypodermis, which is mostly a fat layer that is found just under the skin’s dermal layer. It is now estimated that about 10% of the hypodermis tissue is composed of adipose stem cells, with, approximately, the other 90% being lipid cells. After years of research in skin tissue engineering, adipocyte-derived stem cells have been identified as a key player in the skin regenerative process with a cell-to-cell communication pathway into the dermal and epidermal layers. ASC’s produce a high content of growth factors (substances acting as messengers) to communicate with keratinocytes and stimulate their proliferation, as well as communication to fibroblast cells to produce more collagen and elastin, which are indispensable to the regeneration and renewal of the skin’s epidermal and dermal layers. There is a major connection between both the dermis and the epidermis and the adipose tissue. The three stem cell types communicate and work together for skin renewal, especially when there is trauma.

Technology - adipose cross section
Figure 3 – Cross-section of skin showing Adipose Stem Cells in Hypodermis

 

Combined and Coordinated Activation with SRC-7

All of these various stem cells in human skin work together for the same end … to contribute to epidermal and dermal renewal and regeneration. Given these various studies and research discoveries that have been made in the recent years, the possibility exists that a combined formula could be developed that would provide a unique solution to stimulating all of the various stem cell types pertaining to the skin (especially aging skin), resulting in increased epidermal cell production, increased collagen/elastin production and increased stem cell replication. This type of increased activity would be useful for both improved skin appearance, and for wound healing. Based upon research and proven results, certain ingredients, offering a biochemical “message” performance, could be used to create a combined and coordinated stimulation of all three stem cell types. The protecting and revitalizing of human epidermal, dermal and hypodermal stem cells, by means of a highly effective, individually proven combination of actives should not only help to accelerate the skin’s natural repair process but also mitigate skin appearance damage from age related and environmental factors. This combined formulation provides a means of addressing all three human skin stem cell types (ESC, DSC, & ASC) in one, such that they can perform together the process of skin renewal and rejuvenation. This is a key part of SRC-7. In addition to these combined stem cell activators, an additional component to SRC-7 multiplies the revitalizing impact by actually increasing the active stem cell pool through increased replication of new stem cells.

This increased replication of new stem cells allows for a more highly accelerated rejuvenation of new skin. All of these powerful components, supporting one another for mutual benefit, provide a performance that is beyond the “sum of the parts,” and delivers the most advanced stem cell technology available for skin care today.

 

 

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